Buckeye's lead technology, MACROESISTM (patent pending) shows great clinical promise to overcome earlier limitations and open the door to a broad range of active compounds. It is ideal for delivering efficacious dosages in a non-invasive and safe manner. MACROESISTM goes significantly beyond the promise of iontophoresis by utilizing both AC and DC electrochemistry delivered through disposable electrodes and targeted drug delivery to actively push drugs to where they are needed.
MACROESISTM drug delivery utilizes electokinesis, a low-voltage electric current to induce fluid and particle movement. It involves the application of an electromotive force to transport ions and neutral molecules through a solid or liquid medium, in this case the protective stratum corneum, and into the epidermis. Ionized drugs (charged molecules) are transported actively by the force of the applied electrical field (electrorepulsion). In iontophoresis, like charges repel, so positively charged ions are driven into the skin at the anode (positive electrode), while negatively charged ions are driven into the skin at the cathode (negative electrode). Neutral, water soluble drug molecules are transported by electroosmosis, the bulk fluid flow associated with cation (positively charged molecules) transport by an electric field. Two electrodes are used in conjunction with the patientís skin to form a closed circuit, which allows the flow of current.